Prominent examples of predictable and preventable disorders
Breast Cancer
In 2020, there were 2.3 million women diagnosed with breast cancer (BC) and 685 000 BC-related deaths globally. As of the end of 2020, there were 7.8 million women alive who were diagnosed with BC in the past 5 years, making it the world's most prevalent cancer. There are more lost disability-adjusted life years (DALYs) by women to BC globally than any other type of cancer. BC occurs in every country of the world in women at any age after puberty – see WHO report:
Absolute majority of BC cases are preventable; for that individualised health risks assessment is strongly recommended.
Breast Cancer – Case report
• Female, 41 years old, diagnosed with triple negative multifocal ductal invasive carcinoma of the right breast
• Academic: University graduated zoologist
• Permanently job-occupied as professional zoologist since 24 years of age with two maternity leaves, each lasting 2 years
• Life style: long walks in natural environment; regular aerobic exercising; low calories nutrition; vitamin rich diet; working rhythms – only over the day; regular sleep patterns, spends a lot of time with outdoor- activities in rural environment
• Pronounced vascular dysregulation, altered thermoregulation (feeling cold even when other people around are comfortable with the room temperature), low BMI, shifted circadian rhythm and regulation of senses, strongly pronounced stress reactions
• The life-style habits generally considered as “healthy” might be suboptimal for the patient with this phenotype such as low calories nutrition (due to the low energy supply), much time spent outdoor in the low temperature environment (due to the cold stress provocation), much physical exercises (due to the excessive stress by sport).
• Further persistent conditions of the patient, namely Sicca syndrome (dry skin, dry nose, dry mouth reported by the patient before the chemotherapy application; under the current chemotherapy also the vaginal dryness is an additional complication reported), and allergies (allergic rhinitis and conjuctivitis) – altogether may strongly contribute to systemic inflammation and cancer development; see literature:
pubmed.ncbi.nlm.nih.gov/ 30174766/
pubmed.ncbi.nlm.nih.gov/ 28620440/
pubmed.ncbi.nlm.nih.gov/ 28824738/
pubmed.ncbi.nlm.nih.gov/ 28725292/
pubmed.ncbi.nlm.nih.gov/ 30984316/